Microsoft Word - DMM cathepsin paper FINALR2.docx

Excessive Activity of Cathepsin K is Associated with the Cartilage Defects in a Zebrafish Model for Mucolipidosis II Aaron C. Petrey*, Heather Flanagan-Steet*, Steven Johnson, Xiang Fan, Mitche De la Rosa, Mark E. Haskins, Alison V. Nairn, Kelley W. Moremen, Richard Steet 1 Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA 2 Departments of Pathobiology and Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6051, USA *Authors contributed equally to this work Address correspondence to: Richard A. Steet, Ph.D., Complex Carbohydrate Research Center, 315 Riverbend Road, Athens, GA 30602, fax: (706) 542-4412, email: [email protected] Running title: Role of cathepsins in ML-II pathogenesis